Indications: Heart Failure (NYHA class III and IV) and SIADH (especially if sodium has not responded to fluid restriction)  Contraindications: Hypovolemia, Anuria, Liver Impairment ***Do not use if you have to raise the sodium quickly!*** For more information regarding Tolvaptan: Read Here!

"Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. It has been increasingly reported in the USA due to the rise in the immigrant population. Hypokalemia in TPP results from an … Continue reading TPP and Hypokalemia

Faget Sign: Relative bradycardia in association with fever (Temperature-pulse dissociation). Originally described by Jean-Charles Faget in patients with yellow fever (1859). "Discordance entre la courbe du pouls et celle de la temperature dans la fièvre jaune." Subsequently observed in multiple febrile illnesses especially intracellular bacterial infections.

Treatment with intravenous recombinant tissue plasminogen activator (alteplase) within 3 hours of ischemic stroke onset is associated with a significant reduction in disability at 3 months after stroke; treatment within 4.5 hours of onset also may have clinical benefit but is not FDA approved.